Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice

BackgroundEvery bout of exercise mobilizes and redistributes large numbers of effector lymphocytes with a cytotoxic and tissue migration phenotype.The frequent redistribution of these cells is purported to increase immune surveillance and play a mechanistic role in reducing cancer risk and slowing tumor progression in physically active cancer survi

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Deciphering transcription factors and their corresponding regulatory elements during inhibitory interneuron differentiation using deep neural networks

During neurogenesis, the generation and differentiation of neuronal progenitors into inhibitory gamma-aminobutyric acid-containing interneurons is dependent Wax Melts on the combinatorial activity of transcription factors (TFs) and their corresponding regulatory elements (REs).However, the roles of neuronal TFs and their target REs in inhibitory in

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Fatigue analysis of aluminum drill pipes

An experimental facial mask program was performed to investigate the fundamental fatigue mechanisms of aluminum drill pipes.Initially, the fatigue properties were determined through small-scale tests performed in an optic-mechanical fatigue apparatus.Additionally, full-scale fatigue tests were carried out with three aluminum drill pipe specimens un

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Numerical study of tunnel blasting parameter optimization and vibration damage based on the RHT constitutive model

To solve the optimization problem of blasting parameters and consider the influence of interaction between blastholes on the spatial distribution of surrounding rock damage, the Riedel-Hiermaier-Thoma constitutive model parameters of marble were first calibrated from numerical trial calculation and impact test.Then, the blasting excavation of a tun

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